Co-encapsulation of a Mixture of Antioxidant and Sunscreen Agents into Solid Lipid Nanoparticles

This paper aims to encapsulate into solid lipid nanoparticles a mixture of two bioactive compounds, a photoprotective agent and an antioxidant compound. The co-encapsulation effect of octocrylene sunscreen and flavonoid (luteolinon) has been studied on the specific properties like antioxidant activity, sun protection factor and photostability. Using the high preasure homogenization technique lipid nanoparticles with diameters between 109-132 nm and a polidispersity index between 0.18-0.3 have been obtained. The results obtained shown that adding a photoprotective agent along with the antioxidant compound does not diminish the antioxidant capacity. By measuring the sun protection properties, for a concentration of 1.25 % octocrylene encapsulated in solid lipid nanoparticles and formulated into a cream base, values of sun protection factor higher than 30 have been determined, this meaning that these materials assure good photoprotection. All the results obtained lead to conclusion that co-encapsulating the luteolin with octocrylene in the lipid nanoparticles has a result a higher photoprotection capacity, this fact provinging that solid lipid nanoparticles loaded with these two bioactive compounds may be used as systems for blocking the UV radiations in cosmetics with sunscreen action.